Review Article

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Table 1

Characteristics of the study populations in the included studies.

First author, year, and referenceEthnicityGender Age Study population Outcome

Sousa 2009 [10]BrazilM/F58.4–62.7Nondiabetic subjects, diabetic subjectTC, LDL-c, HDL-c, TG
Muendlein 2011 [12]AustriaM/F63.3–65.9Diabetic subject, nondiabetic subjectsTC, LDL-c, HDL-c, TG
Palizban 2012 [13]IranM/F50.4–59.3Diabetic subject, nondiabetic subjectsTC, TG
Then 2013 [14]GermanM51–58Nondiabetic subjectsTC, LDL-c, HDL-c, TG
Kahveci 2012 [15]TurkeyM/F36–84Diabetic subject and nondiabetic subjectsTC, LDL-c, HDL-c, TG
Bodhini 2007 [16]Asian IndiansM/F41 ± 11Normal glucose tolerant subjectsTC, LDL-c, HDL-c, TG
Warodomwichit 2009 [9]European AmericansM/F17–92 ysThe Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) studyTC, LDL-c, HDL-c, TG
Melzer 2006 [11]White European originM/F≥65 ysOlder population from InCHIATI studyTC, LDL-c, HDL-c, TG
Marquezine 2008 [17]BrazilM/F44.3–59.8Multivessel coronary artery disease patients, general populationTC, HDL-c, TG
Musso 2009 [18]ItalyM/F38–41Healthy control, nonalcoholic fatty liver diseaseTC, LDL-c, HDL-c, TG
Choi 2014 [19]KoreaM/F59-60Diabetic patientsTC, LDL-c, HDL-c, TG
Wang 2013 [20]ChineseM/F20–85Nondiabetic controlsTC, LDL-c, HDL-c, TG
Delgado-Lista 2011 [21]LIPGENE dietary intervention from 8 European countriesM/F35–70 ysMetabolic syndrome according to NCEP criteriaTC, LDL-c, HDL-c, TG
Perez-Martinez 2012 [8]IrelandM/F22–68.4Young men, metabolic syndrome, and healthy elderlyTC, LDL-c, HDL-c, TG
Ramos 2013 [22]BrazilF22.8 ± 6.6Women with polycystic ovary syndromeTC, LDL-c, HDL-c, TG
Gambino 2010 [23]Caucasian, ItalyM/F54.2–54.7Population-based cohortLDL-c, HDL-c
Cauchi 2007 [24]Caucasian, FrenchM/FAround 22Small gestational age, appropriate for gestational age birth weightTC, TG
Cauchi 2006 [25]FrenchM/F30–65NormoglycemicTC, LDL-c, HDL-c, TG
Humphries 2006 [26]European White, Indian Asia, Afro-CaribbeanM/F62.4–63Diabetic patients, healthy subjectsTC, LDL-c, HDL-c, TG
Bo 2009 [27]ItalyM/F55.2–56.8Nondiabetic dysmetabolic participants, controlHDL-c, TG
Ereqat 2010 [28]Palestinian M/F>40 ysDiabetic subject, nondiabetic subjectsTC
Yan 2009 [29]African American, CaucasianM/F53-54The Atherosclerosis Risk in Communities Study (ARIC) LDL-c, HDL-c, TG
Yan 2010 [30]African American, CaucasianM/F58.3–60.1The Atherosclerosis Risk in Communities Study (ARIC)TC
Schroner 2011 [31]SlovakiaM/F62.6–63.1Diabetic subject with HbA1C <7.0%TC, LDL-c, HDL-c, TG