Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015 (2015), Article ID 484721, 8 pages
http://dx.doi.org/10.1155/2015/484721
Research Article

The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression

Guizhou Medical University, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550025, China

Received 18 February 2015; Revised 29 May 2015; Accepted 1 June 2015

Academic Editor: Bernard Portha

Copyright © 2015 Yu He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. A. F. Sima, “Encephalopathies: the emerging diabetic complications,” Acta Diabetologica, vol. 47, no. 4, pp. 279–293, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. J. Biessels and J. A. Luchsinger, Diabetes and the Brain, Humana Press, New York, NY, USA, 2009.
  3. G. Biessels and W. H. Gispen, “The calcium hypothesis of brain aging and neurodegenerative disorders: significance in diabetic neuropathy,” Life Sciences, vol. 59, no. 5-6, pp. 379–387, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. K. E. Cunningham and J. R. Turner, “Myosin light chain kinase: pulling the strings of epithelial tight junction function,” Annals of the New York Academy of Sciences, vol. 1258, no. 1, pp. 34–42, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. T. A. Ryan, “Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing,” Journal of Neuroscience, vol. 19, no. 4, pp. 1317–1323, 1999. View at Google Scholar · View at Scopus
  6. S. Mochida, H. Kobayashi, Y. Matsuda, Y. Yuda, K. Muramoto, and Y. Nonomura, “Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture,” Neuron, vol. 13, no. 5, pp. 1131–1142, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Jian, B. G. Szaro, and J. T. Schmidt, “Myosin light chain kinase: expression in neurons and upregulation during axon regeneration,” Journal of Neurobiology, vol. 31, no. 3, pp. 379–391, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Ruchhoeft and W. A. Harris, “Myosin functions in Xenopus retinal ganglion cell growth cone motility in vivo,” Journal of Neurobiology, vol. 32, no. 6, pp. 567–578, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Li, W. Pan, G. Z. Yang et al., “Proteome analysis of differential protein expression in brain of rats with type 1 diabetes mellitus,” Experimental and Clinical Endocrinology and Diabetes, vol. 119, no. 5, pp. 265–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. A. M. Magariños and B. S. McEwen, “Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, pp. 11056–11061, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Y. Jang, H. N. Kim, Y. R. Kim et al., “Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons,” Journal of Ethnopharmacology, vol. 145, no. 1, pp. 261–268, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. G. L. Dalton, D. C. Wu, Y. T. Wang, S. B. Floresco, and A. G. Phillips, “NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear,” Neuropharmacology, vol. 62, no. 2, pp. 797–806, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Rebola, B. N. Srikumar, and C. Mulle, “Activity-dependent synaptic plasticity of NMDA receptors,” The Journal of Physiology, vol. 588, no. 1, pp. 93–99, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Lei, E. Czerwinska, W. Czerwinski, M. P. Walsh, and J. F. MacDonald, “Regulation of NMDA receptor activity by F-actin and myosin light chain kinase,” Journal of Neuroscience, vol. 21, no. 21, pp. 8464–8472, 2001. View at Google Scholar · View at Scopus
  15. K. E. Kamm and J. T. Stull, “Dedicated myosin light chain kinase with diverse cellular functions,” The Journal of Biological Chemistry, vol. 276, no. 7, pp. 4527–4530, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Gao, J. Huang, W. He, M. Zhu, K. E. Kamm, and J. T. Stull, “Signaling through myosin light chain kinase in smooth muscles,” The Journal of Biological Chemistry, vol. 288, no. 11, pp. 7596–7605, 2013. View at Publisher · View at Google Scholar · View at Scopus