Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis

Figure 2

(a) Representative tapping mode atomic force microscopy image (amplitude mode) of IAPP amyloid fibrils prepared in homogenous solution (50 μM at 37°C for 24 h.). (b) Schematic representation of the general cross-β-sheet quaternary structure of amyloids showing the interstrand (≅4.7 Å) and intersheet (≅10 Å) distances.

(a)

(b)