Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions

Figure 1

Mean and standard deviation of body weight gain (a), prostate wet weight (b), prostate relative weight (c), blood glucose levels (d), and serum testosterone (e). C1: short-term control; M1: short-term control treated with MLT; D1: short-term untreated diabetic; MD1: short-term diabetic treated with MLT; C2: long-term control; M2: long-term control treated with MLT; D2: long-term untreated diabetic; and MD2: long-term diabetic treated with MLT. Light bars: short-term experiment and dark bars: long-term experiment ( animals/group). Different lowercase letters indicate significant differences between experimental groups C1, M1, D1, and MD1 (parametric data: prostate weight, relative prostate weight, and serum testosterone; nonparametric data: body weight gain, glycemia), and different capital letters indicate significant differences between groups C2, M2, D2, and MD2 (parametric data: body weight gain, prostate weight, relative prostate weight, and serum testosterone; nonparametric data: glycemia). ignificant difference between experimental periods (t-test or Mann-Whitney U test).

(a)

(b)

(c)

(d)

(e)