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Journal of Diabetes Research
Volume 2015 (2015), Article ID 538732, 7 pages
Research Article

Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control

1Departamento de Educação Física da Universidade Estadual do Centro-Oeste (UNICENTRO), Rua Simeão Camargo Varela de Sá, 03, 85040-080 Guarapuava, PR, Brazil
2Departamento de Educação Física da Universidade Estadual Paulista (UNESP), Avenida 24 A 1515, 13506-900 Rio Claro, SP, Brazil
3Departamento de Análises Clínicas e Toxicológicas da Universidade Federal do Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, 384, 59012-570 Natal, RN, Brazil
4Departamento de Análises Clínicas e Toxicológicas da Universidade de São Paulo (USP), Avenida Professor Lineu Prestes, 580, 05508-000 São Paulo, SP, Brazil

Received 22 October 2014; Revised 22 February 2015; Accepted 1 March 2015

Academic Editor: Norman Cameron

Copyright © 2015 Marcos Roberto Queiroga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured. Twins from the discordant group had differences in VO2max values (D-high = versus D-low =  mL·kg−1·min−1, ), while no differences were found in the concordant group (C-high = versus C-low =  mL·kg−1·min−1, ). In discordant group, VO2max was negatively correlated with TR + SB (, ) and positively correlated with PPARG expression in leukocytes (, ). Moreover, PPARG expression was directly correlated with BM (, ) and height (, ). In concordant twins, VO2max was inversely correlated with BM (, ), BMI (, ), WC (, ), and TR + SB (, ). Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (). In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.