Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells

Figure 2

Proteome architecture of intermediary metabolic pathways in rat and human islet endocrine cells. Data represent mean ± SD geometrically normalized protein amounts in rat beta (black bars, ), rat alpha (white bars, ), and human beta cells (gray bars, ). No error bar means confident detection in just 1 biological replicate. Proteins are denoted by their official gene symbol as recorded by UniProt (May 2014) and grouped for their main metabolic pathway: (a) glycolysis, (b) NADH/FADH2 shuttles. (c) Krebs cycle and ana- or cataplerosis. (d) Mitochondrial Electron Transport Complexes I–V. Full width at half maximum can be used as statistical discrimination limit for differential protein expression, corresponding to 2.35 times the median total error (19%) = 45%.

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