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Journal of Diabetes Research
Volume 2015, Article ID 587673, 8 pages
Research Article

Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study

1Division of Diabetes and Nutritional Sciences, King’s College London, Diabetes Research Group, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
2Department of Psychological Medicine, King’s College London, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
3Paxton Green Group Practice, 1 Alleyn Park, London SE21 8AU, UK
4Department of Ophthalmology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9PJ, UK

Received 8 February 2015; Revised 12 April 2015; Accepted 28 April 2015

Academic Editor: Mitsuhiko Noda

Copyright © 2015 Mohsin Azam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. WHO’s recommendation of  mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed before May 2012 with  mmol/mol to those with diagnostic  mmol/mol. Methods. A prospective cohort study of newly diagnosed T2DM participants from 96 primary care practices, comparing demographic and biomedical variables between those with diagnostic  mmol/mol or  mmol/mol at recruitment and after one year. Results. Of 1488 participants, 22.8% had diagnostic  mmol/mol. They were older and more likely to be white (). At recruitment and one year, there were no between-group differences in the prevalence of diabetic complications, except that those diagnosed with  mmol/mol had more sensory neuropathy at recruitment () and, at one year, had new myocardial infarction () but less microalbuminuria (). Conclusions. Use of  mmol/mol as the sole T2DM diagnostic criterion may miss almost a quarter of those previously diagnosed in South London yet  mmol/mol may not exclude clinically important diabetes.