Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

Figure 2

Effect of low glucose (LG) and glucose (G) on left ventricular end-diastolic pressure (LVEDP) and left ventricle developed pressure (LVDP) during ischemia reperfusion. LVEDP is not only a marker of diastolic function but also a good predictor of cardiac mortality independent of LV ejection fraction. LVDP was calculated by subtracing LVEDP, from LV peak systolic pressure (LVSP). There was significantly increase in LVEDP and decrease in LVDP in LG as compared to G (all ). Propofol significantly improved cardiac function in G but not in LG. TMZ facilitated propofol cardioprotection in LG. Values are presented as mean ± SEM. per group. versus BS20; versus LG; versus LG+P; versus G.

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