Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials

Figure 1

DPP4 molecular structure: DPP4 consists of a 6-amino-acid cytoplasmic tail, a 22-amino-acid transmembrane domain, and a large extracellular domain. The extracellular domain is responsible for the dipeptidyl-peptidase activity and binding to its ligands such as ADA and fibronectin. AA, amino acid; ADA, adenosine deaminase.