Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials

Figure 3

Role of ADA-DPP4 interaction in adenosine clearance: by binding to DPP4 on the cell surface, ADA reduces pericellular levels of cytotoxic metabolite adenosine by converting it into a nontoxic product inosine.