Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 636891, 5 pages
http://dx.doi.org/10.1155/2015/636891
Research Article

The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and  β-Cell Function in Newly Diagnosed Type 2 Diabetes

1Department of Endocrinology, The Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin 214400, China
2Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210036, China

Received 11 November 2014; Accepted 20 January 2015

Academic Editor: Liping Yu

Copyright © 2015 Yuan Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Shankar, C. Sabanayagam, and S. Kalidindi, “Serum 25-hydroxyvitamin D levels and prediabetes among subjects free of diabetes,” Diabetes Care, vol. 34, no. 5, pp. 1114–1119, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Targher, L. Bertolini, R. Padovani et al., “Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients,” Clinical Endocrinology, vol. 65, no. 5, pp. 593–597, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Mattila, P. Knekt, S. Männistö et al., “Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes,” Diabetes Care, vol. 30, no. 10, pp. 2569–2570, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Lim, M. J. Kim, S. H. Choi et al., “Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects1-4,” American Journal of Clinical Nutrition, vol. 97, no. 3, pp. 524–530, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Wu, W. C. Willett, and E. Giovannucci, “Plasma C-peptide is inversely associated with calcium intake in women and with plasma 25-hydroxy vitamin D in men,” Journal of Nutrition, vol. 139, no. 3, pp. 547–554, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Kayaniyil, R. Vieth, R. Retnakaran et al., “Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes,” Diabetes Care, vol. 33, no. 6, pp. 1379–1381, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Matsuda and R. A. DeFronzo, “Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp,” Diabetes Care, vol. 22, no. 9, pp. 1462–1470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Stancáková, M. Javorský, T. Kuulasmaa, S. M. Haffner, J. Kuusisto, and M. Laakso, “Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men,” Diabetes, vol. 58, no. 5, pp. 1212–1221, 2009. View at Google Scholar
  10. R. Retnakaran, S. Shen, A. J. Hanley, V. Vuksan, J. K. Hamilton, and B. Zinman, “Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test,” Obesity, vol. 16, no. 8, pp. 1901–1907, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Stivelman and R. Retnakaran, “Role of vitamin D in the pathophysiology and treatment of type 2 diabetes,” Current Diabetes Reviews, vol. 8, no. 1, pp. 42–47, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Blum, G. Dolnikowski, E. Seyoum et al., “Vitamin D 3 in fat tissue,” Endocrine, vol. 33, no. 1, pp. 90–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Zhao, E. S. Ford, and C. Y. Li, “Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among US adults without physician-diagnosed diabetes: NHANES, 2003–2006,” Diabetes Care, vol. 33, no. 2, pp. 344–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Maestro, S. Molero, S. Bajo, N. Dávila, and C. Calle, “Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3,” Cell Biochemistry and Function, vol. 20, no. 3, pp. 227–232, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. T. W. Dunlop, S. Väisänen, C. Frank et al., “The human peroxisome proliferator-activated receptor δ gene is a primary target of 1α,25-dihydroxyvitamin D3 and its nuclear receptor,” Journal of Molecular Biology, vol. 349, no. 2, pp. 248–260, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Cohen-Lahav, S. Shany, D. Tobvin, C. Chaimovitz, and A. Douvdevani, “Vitamin D decreases NFκB activity by increasing IκBα levels,” Nephrology Dialysis Transplantation, vol. 21, no. 4, pp. 889–897, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. K. L. Jablonski, M. Chonchol, G. L. Pierce, A. E. Walker, and D. R. Seals, “25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults,” Hypertension, vol. 57, no. 1, pp. 63–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. A. Peterson and M. E. Heffernan, “Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women,” Journal of Inflammation, vol. 5, article 10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. A. Johnson, J. P. Grande, P. C. Roche, and R. Kumar, “Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas,” AM.J.PHYSIOL., vol. 267, no. 3, pp. E356–E360, 1994. View at Google Scholar · View at Scopus
  20. I. N. Sergeev and W. B. Rhoten, “1,25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic β-cell line,” Endocrinology, vol. 136, no. 7, pp. 2852–2861, 1995. View at Google Scholar · View at Scopus
  21. B. K. Lee, S. Park, and Y. Kim, “Age- and gender-specific associations between low serum 25-hydroxyvitamin D level and type 2 diabetes in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data,” Asia Pacific Journal of Clinical Nutrition, vol. 21, no. 4, pp. 536–546, 2012. View at Google Scholar · View at Scopus
  22. J. Mitri, B. Dawson-Hughes, F. B. Hu, and A. G. Pittas, “Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial,” American Journal of Clinical Nutrition, vol. 94, no. 2, pp. 486–494, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. P. R. von Hurst, W. Stonehouse, and J. Coad, “Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient—a randomised, placebo-controlled trial,” British Journal of Nutrition, vol. 103, no. 4, pp. 549–555, 2010. View at Publisher · View at Google Scholar · View at Scopus