Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin

Figure 3

ACE activity (mU/mg of protein) in renal tissue of CT (white column) and D (black column) mice having 1 or 3 copies of the Ace gene at the end of twelve weeks of experimental period, assessed using two specific ACE substrates: (a) HHL and (b) Zphe-HL. Values represent mean ± S.E.M., . Two-way ANOVA showed : diabetic versus control. : 3 copies control group versus 1 copy control group.

(a)

(b)