Research Article

An Altered Pattern of Myocardial Histopathological and Molecular Changes Underlies the Different Characteristics of Type-1 and Type-2 Diabetic Cardiac Dysfunction

Figure 4

Characteristic changes in myocardial expression of genes involved in the development of diabetic cardiomyopathy (a) and genes of endogenous antioxidants (b) in type-1 and type-2 diabetes mellitus (DM) models. Relative mRNA expression for (a) hypertrophy markers α myosin heavy chain (MHC), β-MHC, early genes of the hypertrophic transcriptional program c-fos and c-jun; extracellular matrix components collagens 1 and 3, vascular endothelial marker endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1); atrial natriuretic factor (ANF) and proapoptotic caspase-12, as well as for (b) endogenous antioxidants superoxide dismutase 1 (SOD1) and 2 (SOD2), catalase, glutathione reductase and thioredoxin in the groups of SD control, streptozotocin- (STZ-) induced diabetic SD, Zucker Diabetic Fatty (ZDF) lean and ZDF diabetic rats. Bar graphs represent mean ± SEM. Percent changes between diabetic and corresponding nondiabetic control groups are indicated in both DM models. *: versus the corresponding nondiabetic group.