Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22

Figure 4

imp knockdown mutant exhibited longer lifespan and reduced starvation resistance. (a) Survival of elav-Gal4 virgin flies (blue, ), UAS-imp (green, ), and imp mutant [elav-Gal4; UAS-imp] (orange, ). Median lifespans are as follows: elav-Gal4, 51 days; UAS-imp; UAS-Dicer2, 40 days; elav-Gal4; UAS-imp 62 days, versus elav-Gal4, versus UAS-imp (log-rank test). (b) Survival of virgin flies during starvation: elav-Gal4 virgin flies (blue, ), UAS-imp (green, ), and imp mutant [elav-Gal4; UAS-imp] (orange, ). Average lifespans are as follows: elav-Gal4, days; UAS-imp days; imp mutant [elav-Gal4; UAS-imp] days, versus elav-Gal4, versus UAS-imp (log-rank test).

(a)

(b)