Research Article

Healthy Chilean Adolescents with HOMA-IR 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

Table 2

Association between IR and sex, obesity, sarcopenia, low adiponectin, life-style habits, and HFDM2 in adolescents ().

Subjects with insulin resistance (HOMA-IR ≥ 2.6)Crude ORa
%

Overall10916.32
Obesity
 No6511.4Ref. group
 Yes4445.86.60 4.09–10.6***
Sarcopenia
 No5010.8Ref. group
 Yes5935.14.87 3.17–7.50***
Low adiponectin
 No7413.6Ref. group
 Yes3528.52.53 1.59–4.01***
Physical inactivity
 No5313.2Ref. group
 Yes5621.11.77 1.17–2.67***
Unhealthy food intake
 No8917.5Ref. group
 Yes2012.60.68 0.40–1.14***
Family history T2Db
 No2311.7Ref. group
 Yes7418.81.73 1.10–2.88***

Statistical significance: *P < 0.05, **P < 0.01, and ***P < 0.001; obesity: BMI -score ≥2 SD; sarcopenia: % FFMI ≤25th percentile; low adiponectin: adiponectin ≤7.9 g/mL; physical inactivity: PA score ≤3; unhealthy food intake: eating test score ≤4.4; FHDMb:family history of type 2 diabetes in at least one first-degree relative ().