Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

Table 3

Influence of FHDM, physical inactivity, sarcopenia, obesity, and low adiponectin over the risk of insulin resistance ().

	Model 1	Model 2	Model 3	Model 4
	OR 95% CI	OR 95% CI	OR 95% CI	OR 95% CI
FHDM	1.74 1.10–2.88^*	1.74 1.10–2.94^*	1.72 1.10–2.92^*	1.80 1.10–3.08^*
Physical inactivity	1.77 1.14–2.75^*	1.49 0.94–2.37	1.42 0.89–2.26	1.45 0.90–2.34
Sarcopenia	(⋯)	4.25 2.67–6.75^***	2.27 1.25–4.12^**	2.56 1.21–4.07^**
Obesity	(⋯)	(⋯)	3.25 1.71–6.19^***	2.92 1.51–5.66^**
Low adiponectin	(⋯)	(⋯)	(⋯)	2.22 1.30–3.77^**
Likelihood ratio (Chi2)	11.46^**	48.5^***	61.6^***	69.8^***
Hosmer-Lemeshow	<0.001 (0.99)	0.39 (0.99)	0.18 (0.99)	1.21 (0.98)
Correctly classified	83.6%	83.6%	84.2%	84.6%

OR 95% CI: odd ratio 95% confidence interval. Statistical significance: ^*P < 0.05; ^**P < 0.01; ^***P < 0.001. ⋯: nonobserved. OR 95% CI: odd ratio [95% confidence interval]. FHDM: family history of type 2 diabetes in at least one first-degree relative. Obesity: BMI score ≥2 SD; sarcopenia: FFMI ≤25th percentile; physical inactivity: PA score ≤3; low adiponectin: adiponectin ≤7.9 g/mL.