Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice
Long-acting, glucose lowering effect of E2HSA following oral glucose challenge in normal ICR mice administered a single dose. ((a)-(b)) Curves of blood glucose and AUC after first oral glucose loading performed at 20 minutes after administration of E2HSA. ((c)-(d)) Curves of blood glucose and AUC after second oral glucose challenge carried out at 4 hours after administration. (e) Blood glucose levels at fasting state and 30 minutes after oral glucose challenge on the 2nd day to 7th day after administration. Nor., normal ICR mice administered normal saline. Exendin-4, exendin-4 treated group. Data are expressed as mean ± S.E.M (). , , and versus Nor.
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