Effects of E2HSA, a Long-Acting Glucagon Like Peptide-1 Receptor Agonist, on Glycemic Control and Beta Cell Function in Spontaneous Diabetic db/db Mice

Figure 5

Effects of E2HSA on islet hormone secretion and plasma lipid levels in spontaneous type 2 diabetes db/db mice. (a) Fasting plasma insulin levels at the 2nd week. (b) Plasma insulin levels at 2 minutes and 5 minutes after intravenous glucose challenge in IVGTT. (c) Fasting plasma glucagon levels at the end of the experiment. ((d)–(f)) Fasting plasma triglyceride levels from the 5th week (d), fasting total plasma cholesterol levels from the 1st week (e), and fasting plasma FFA levels from the 2nd week (f) were represented here. Nor., db/m mice administered normal saline. Con., db/db mice administered normal saline. Data are expressed as mean ± S.E.M (-11). , , and versus Con.

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