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Journal of Diabetes Research
Volume 2015, Article ID 846807, 6 pages
http://dx.doi.org/10.1155/2015/846807
Research Article

The Effects of Atorvastatin on Arterial Stiffness in Male Patients with Type 2 Diabetes

1Department of Academic Endocrinology, Beaumont Hospital, Dublin, Ireland
2School of Health and Human Performance, Dublin City University, Dublin, Ireland

Received 11 December 2014; Revised 1 April 2015; Accepted 9 April 2015

Academic Editor: Secundino Cigarran

Copyright © 2015 Colin Davenport et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fifty-one patients ceased statin therapy for 6 weeks, followed by randomisation to either 10 or 80 mg of atorvastatin. At randomization, 3 and 12 months, central arterial stiffness was measured via carotid-femoral pulse wave velocity (PWV), along with serum markers of vascular inflammation including high-sensitivity c-reactive protein (hsCRP) and osteoprotegerin (OPG). PWV decreased from 10.37 ± 1.30 to 9.68 ± 1.19 m/sec ( from baseline) at 3 months and 9.10 ± 1.17 m/sec ( from baseline) at 12 months. hsCRP and OPG decreased significantly at 3 and 12 months. Reductions in PWV did not differ significantly between the groups. Baseline PWV and OPG values correlated strongly (, ), as did their response to atorvastatin over 12 months ( delta-OPG and delta-PWV, ). Atorvastatin therapy appeared to reduce central arterial stiffness in male type 2 diabetes, with no dose-dependent effect observed. The correlation observed between reductions in PWV and OPG suggests that atorvastatin reduces PWV via direct anti-inflammatory effects on the vasculature.