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Journal of Diabetes Research
Volume 2015, Article ID 847674, 10 pages
http://dx.doi.org/10.1155/2015/847674
Research Article

The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth

1Department of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1
2Department of Physiology and Pharmacology, Western University, London, ON, Canada N6A 5C1
3Lawson Health Research Institute, London, ON, Canada N6C 2R5
4Department of Family Relations and Applied Nutrition, Guelph, ON, Canada N1G 2W1
5Department of Obstetrics and Gynaecology, Western University, London, ON, Canada N6H 5W9
6Department of Paediatrics, Western University, London, ON, Canada N6C 2R6
7Children’s Health Research Institute, London, ON, Canada N6C 2V5

Received 16 December 2014; Accepted 30 March 2015

Academic Editor: Dennis Mook-Kanamori

Copyright © 2015 Erin Graves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. Results. High maternal BMI ( (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (, versus , ). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction. Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.