Table 2: Comparing the diagnostic performance of Neuropad between the continuous and the categorical output. The evaluation was performed against large (Neuropathy Disability Score (NDS) and Vibration Perception Threshold (VPT), sural sensory nerve action potential (SNAP), sural nerve conduction velocity (SNCV), peroneal motor nerve action potential (PMNAP), and peroneal motor nerve conduction velocity (PMNCV)) and small (intraepidermal nerve fibre density (IENFD), Corneal Nerve Fibre Density (CNFD), Corneal Nerve Branch Density (CNBD), Corneal Nerve Fibre Length (CNFL), Deep Breathing-Heart Rate Variability (DB-HRV), and warm perception thresholds (WPT)) nerve fibre assessments as reference methods using ROC curve analysis.

VariablesContinuous outputCategorical output value of AUC
AUC
%
Sensitivity & Specificity
%
AUC
%
Sensitivity and Specificity
%

Large fibre assessments
NDS (>2)6771, 586669, 620.46
VPT (>14 V)7580, 716670, 570.33
SNAP (<3 μV)8685, 8382100, 550.35
SNCV (<43 m/s)6266, 616161, 590.46
PMNAP (<2 μV) 6367, 546162, 500.44
PMNCV (<42 m/s)6062, 585760, 530.39

Small fibre assessments
IENFD (<4 no./mm)6365, 545556, 510.27
CNFD (<24 no./mm2)8288, 787989, 630.37
CNBD (<18 no./mm2)7983, 7271100, 470.32
CNFL (<14 mm/mm2)8089, 757190, 500.26
DB-HRV (<10 beats per min)9191, 837882, 590.06
WPT (>42°C)6975, 606669, 530.38