Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model

Figure 6

Pancreatic islet insulin release assay. Intact islets alone secreted distinct amount of insulin in response to stimulatory medium (6.45 ± 0.69 ng/mL). However, the insulin secretion levels decreased after coculture with diabetic splenocytes (2.59 ± 0.27 ng/mL). Interestingly, addition of AT-MSCs improved insulin secretion by injured islets (3.87 ± 0.41 ng/mL). Data presented the mean ± SD of five independent experiments. indicates significant difference between groups (). SP N: normal splenocytes; SP D: diabetic splenocytes; islet: mouse pancreatic islet.