The PI3K/Akt Signaling Pathway Mediates the High Glucose-Induced Expression of Extracellular Matrix Molecules in Human Retinal Pigment Epithelial Cells
Effect of a high glucose concentration on the expression of fibronectin, collagen IV, and laminin protein in RPE cells. (a, b, c) A western blot analysis demonstrated that the protein expression of fibronectin, collagen IV, and laminin was upregulated when exposed to high glucose conditions for 24 h in RPE cells. NG and HG represent the normal glucose group and the high glucose group. The data represent the of three independent experiments. versus NG.