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Journal of Diabetes Research
Volume 2015 (2015), Article ID 921274, 10 pages
http://dx.doi.org/10.1155/2015/921274
Research Article

Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins

1Department of Dietetics and Nutrition, Robert Stempel College of Public Health, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
2Department of Biostatistics, Robert Stempel College of Public Health, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
3School of Health Sciences, Liverpool Hope University, Hope Park, Liverpool L16 9JD, UK

Received 26 September 2014; Revised 25 March 2015; Accepted 26 March 2015

Academic Editor: Georgia Fousteri

Copyright © 2015 Amanpreet K. Cheema et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans ( cases and controls) and African Americans ( cases and controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, ) and rs4235308 (OR = 0.42, ) showed protective association with T2D in Haitian Americans. In African Americans, however, rs4235308 showed significant risk association with T2D (OR = 2.53, ). After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, ) and rs7656250 (OR = 0.23, ) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, ). The trends observed for genetic association of PPARGC1A SNPs, rs4235308, and rs7656250 for T2D between Haitian Americans and African Americans point out differences in Black race and warrant replicative study with larger sample size.