Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 921274, 10 pages
http://dx.doi.org/10.1155/2015/921274
Research Article

Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins

1Department of Dietetics and Nutrition, Robert Stempel College of Public Health, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
2Department of Biostatistics, Robert Stempel College of Public Health, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
3School of Health Sciences, Liverpool Hope University, Hope Park, Liverpool L16 9JD, UK

Received 26 September 2014; Revised 25 March 2015; Accepted 26 March 2015

Academic Editor: Georgia Fousteri

Copyright © 2015 Amanpreet K. Cheema et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. Lehman, P. M. Barger, A. Kovacs, J. E. Saffitz, D. M. Medeiros, and D. P. Kelly, “Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis,” Journal of Clinical Investigation, vol. 106, no. 7, pp. 847–856, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. J. M. Huss, R. P. Kopp, and D. P. Kelly, “Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and –gamma: identification of novel Leucine-rich interaction motif within PGC-1alpha,” The Journal of Biological Chemistry, vol. 277, no. 43, pp. 40265–40274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Handschin and B. M. Spiegelman, “Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism,” Endocrine Reviews, vol. 27, no. 7, pp. 728–735, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Gerhart-Hines, J. T. Rodgers, O. Bare et al., “Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α,” EMBO Journal, vol. 26, no. 7, pp. 1913–1923, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. P. J. Fernandez-Marcos and J. Auwerx, “Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis,” The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 884S–890S, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. Wu, P. Puigserver, U. Andersson et al., “Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1,” Cell, vol. 98, no. 1, pp. 115–124, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. L. F. Michael, Z. Wu, R. B. Cheatham et al., “Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 7, pp. 3820–3825, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Miura, Y. Kai, M. Ono, and O. Ezaki, “Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles,” The Journal of Biological Chemistry, vol. 278, no. 33, pp. 31385–31390, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Oberkofler, V. Linnemayr, R. Weitgasser et al., “Complex haplotypes of the PGC-1α gene are associated with carbohydrate metabolism and type 2 diabetes,” Diabetes, vol. 53, no. 5, pp. 1385–1393, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Gillberg, S. Jacobsen, R. Ribel-Madsen et al., “Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?” PLoS ONE, vol. 8, no. 3, Article ID e58384, 2013. View at Publisher · View at Google Scholar
  11. E. Chapp-Jumbo, C. Edeoga, J. Wan, and S. Dagogo-Jack, “Ethnic disparity in hemoglobin A1c levels among normoglycemic offspring of parents with type 2 diabetes mellitus,” Endocrine Practice, vol. 18, no. 3, pp. 356–362, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. B. Schulze and F. B. Hu, “Primary prevention of diabetes: what can be done and how much can be prevented?” Annual Review of Public Health, vol. 26, pp. 445–467, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Hansen and O. Pedersen, “Genetics of type 2 diabetes mellitus: status and perspectives,” Diabetes, Obesity and Metabolism, vol. 7, no. 2, pp. 122–135, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Köbberling and H. Tillil, “Genetic and nutritional factors in the etiology and pathogenesis of diabetes mellitus,” World Review of Nutrition and Dietetics, vol. 63, pp. 102–115, 1990. View at Google Scholar · View at Scopus
  15. K. M. V. Narayan, J. P. Boyle, T. J. Thompson, S. W. Sorensen, and D. F. Williamson, “Lifetime risk for diabetes mellitus in the United States,” Journal of the American Medical Association, vol. 290, no. 14, pp. 1884–1890, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. J. V. Neel, “The study of natural selection in primitive and civilized human populations,” Human Biology, vol. 61, no. 5-6, pp. 781–810, 1989. View at Google Scholar · View at Scopus
  17. A. Rosen, I. Sharpe, J. Rosen, M. Doddard, and M. Abad, “The prevalence of type 2 diabetes in the Miami-Haitian community,” Ethnicity & Disease, vol. 17, supplement 5, pp. S53–S54, 2007. View at Google Scholar · View at Scopus
  18. F. Zephir, The Haitian Americans (The New Americans), Greenwood Publishing Group, 2004.
  19. Haitian American Community Development Corporation, 2015, http://www.haitianamericancdc.org/community-overview/.
  20. J. S. Carter, J. A. Pugh, and A. Monterrosa, “Non-insulin dependent diabetes mellitus in minorities in United States,” Annals of Internal Medicine, vol. 125, no. 3, pp. 221–232, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. I. M. El-Kebbi, C. B. Cook, D. C. Ziemer, C. D. Miller, D. L. Gallina, and L. S. Phillips, “Association of younger age with poor glycemic control and obesity in urban African Americans with type 2 diabetes,” Archives of Internal Medicine, vol. 163, no. 1, pp. 69–75, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. W. A. Wolfe, “Obesity and the African-American woman: a cultural tolerance of fatness or other neglected factors?” Ethnicity and Disease, vol. 10, no. 3, pp. 446–453, 2000. View at Google Scholar · View at Scopus
  23. C. Agyemang, R. Bhopal, and M. Bruijnzeels, “Negro, black, black African, African Caribbean, African American or what? Labelling African origin populations in the health arena in the 21st century,” Journal of Epidemiology & Community Health, vol. 59, no. 12, pp. 1014–1018, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Cooper and R. David, “The biological concept of race and its application to public health and epidemiology,” Journal of Health Politics, Policy and Law, vol. 11, no. 1, pp. 97–116, 1986. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Cheema, G. G. Zarini, J. Exebio et al., “Ethnic differences in insulin resistance, adiponectin levels and abdominal obesity: Haitian Americans and African Americans, with and without type 2 diabetes mellitus,” British Journal of Medicine and Medical Research, vol. 4, no. 26, pp. 11–20, 2014. View at Publisher · View at Google Scholar
  26. C. Ling, S. del Guerra, R. Lupi et al., “Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion,” Diabetologia, vol. 51, no. 4, pp. 615–622, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Ek, G. Andersen, S. A. Urhammer et al., “Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus,” Diabetologia, vol. 44, no. 12, pp. 2220–2226, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Hara, K. Tobe, T. Okada et al., “A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes,” Diabetologia, vol. 45, no. 5, pp. 740–743, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Song, Y.-Y. Liu, Y. Long et al., “PPARGC1A gene Thr394Thr G/A polymorphism and its association with type 2 diabetes mellitus and insulin resistance in a Chinese population,” Zhonghua Yi Xue Yi Chuan Xue Za Zhi, vol. 27, no. 5, pp. 550–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. K.-H. Zhang, Q. Huang, X.-P. Dai et al., “Effects of the peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) Thr394Thr and Gly482Ser polymorphisms on rosiglitazone response in Chinese patients with type 2 diabetes mellitus,” Journal of Clinical Pharmacology, vol. 50, no. 9, pp. 1022–1030, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Bhat, A. Koul, E. Rai, S. Sharma, and M. K. Dhar, “PGC-1alpha Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study,” Human Genetics, vol. 121, no. 5, pp. 609–614, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. L. Muller, C. Bogardus, O. Pedersen, and L. Baier, “A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor γ coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians,” Diabetes, vol. 52, no. 3, pp. 895–898, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Lacquemant, M. Chikri, P. Boutin, C. Samson, and P. Froguel, “No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and type II diabetes in French Caucasians,” Diabetologia, vol. 45, no. 4, pp. 602–603, 2002. View at Google Scholar
  34. V. G. Vimalananda, J. L. Rosenzweig, H. J. Cabral, M. M. David, and K. E. Lasser, “Comparison of diabetes control among Haitians, African Americans, and non-Hispanic whites in an urban safety-Net Hospital,” Diabetes Care, vol. 34, no. 1, pp. 58–60, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. F. G. Huffman, J. A. Vaccaro, J. C. Exebio, G. G. Zarini, T. Katz, and Z. Dixon, “Television watching, diet quality, and physical activity and diabetes among three ethnicities in the United States,” Journal of Environmental and Public Health, vol. 2012, Article ID 191465, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. E. D. Jean-Baptiste, P. Larco, N. Charles-Larco, C. Vilgrain, D. Simon, and R. Charles, “Glucose intolerance and other cardiovascular risk factors in Haiti (PREDIAH),” Diabetes & Metabolism, vol. 32, no. 5, part 1, pp. 443–451, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. I. Shai, R. Jiang, J. E. Manson et al., “Ethnicity, obesity, and risk of type 2 diabetes in women: a 20-year follow-up study,” Diabetes Care, vol. 29, no. 7, pp. 1585–1590, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. F. L. Brancati, W. H. L. Kao, A. R. Folsom, R. L. Watson, and M. Szklo, “Incident type 2 diabetes mellitus in African American and white adults: the atherosclerosis risk in communities study,” Journal of the American Medical Association, vol. 283, no. 17, pp. 2253–2259, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Villegas, S. M. Williams, Y.-T. Gao et al., “Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes,” Annals of Human Genetics, vol. 78, no. 1, pp. 23–32, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Zhu, Y. Liu, X. Wang et al., “Evaluation of the association between the PPARGC1A genetic polymorphisms and type 2 diabetes in Han Chinese population,” Diabetes Research and Clinical Practice, vol. 86, no. 3, pp. 168–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. C.-Q. Lai, K. L. Tucker, L. D. Parnell et al., “PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican health study,” Diabetes, vol. 57, no. 4, pp. 809–816, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Su, S.-B. Peng, Z.-Q. Li, and Q.-Y. Huang, “Association study between PPARGC1A Thr394Thr/Gly482Ser polymorphisms and type 2 diabetes,” Yi Chuan, vol. 30, no. 3, pp. 304–308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Jing, H. Xueyao, and J. Linong, “Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population,” Endocrine, vol. 42, no. 2, pp. 307–320, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Puigserver, Z. Wu, C. W. Park, R. Graves, M. Wright, and B. M. Spiegelman, “A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis,” Cell, vol. 92, no. 6, pp. 829–839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Rhee, Y. Inoue, J. C. Yoon et al., “Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 4012–4017, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. T. Rodgers, C. Lerin, W. Haas, S. P. Gygi, B. M. Spiegelman, and P. Puigserver, “Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1,” Nature, vol. 434, no. 7029, pp. 113–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. B. N. Finck and D. P. Kelly, “Peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease,” Circulation, vol. 115, no. 19, pp. 2540–2548, 2007. View at Publisher · View at Google Scholar · View at Scopus