Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
Table 5
(a) Associations of the single nucleotide polymorphisms of PPARGC1A with type 2 diabetes by ethnicities in males. (b) Associations of the single nucleotide polymorphisms of PPARGC1A with type 2 diabetes by ethnicity in females.
(a)
Male
Variables
Haitian American
African Americans
OR
95% CI
value
OR
95% CI
value
rs8192678
TT + CT versus CC
0.89
0.25
3.10
0.854
0.86
0.29
2.53
0.786
rs7656250
CC + CT versus TT
1.62
0.51
5.09
0.409
0.37
0.14
0.97
0.043
rs4235308
CC + CT versus TT
0.62
0.24
1.61
0.326
1.16
0.50
2.68
0.723
rs11724368
CC + CG versus GG
0.84
0.23
3.08
0.790
1.11
0.42
2.94
0.829
Note: the statistically significant results are in bold. Controlled variables included in the logistic regression analysis for OR (adjusted) were age, sex, BMI, and smoking status. OR: odds ratio; CI: confidence interval; PPARGC1A: peroxisome proliferator activated receptor, gamma, coactivator 1 alpha.
(b)
Female
Variables
Haitian American
African Americans
OR
95% CI
value
OR
95% CI
value
rs8192678
TT + CT versus CC
0.51
0.15
0.16
0.257
0.48
0.15
1.49
0.205
rs7656250
CC + CT versus TT
0.23
0.08
0.65
0.006
1.14
0.43
3.07
0.788
rs4235308
CC + CT versus TT
0.38
1.59
0.89
0.026
2.69
1.11
6.52
0.029
rs11724368
CC + CG versus GG
1.41
0.45
4.40
0.555
0.32
0.07
1.54
0.155
Note: the statistically significant results are in bold. Controlled variables included in the logistic regression analysis for OR (adjusted) were age, sex, BMI, and smoking status. OR: odds ratio; CI: confidence interval; PPARGC1A: peroxisome proliferator activated receptor, gamma, coactivator 1 alpha.
