Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 954701, 6 pages
http://dx.doi.org/10.1155/2015/954701
Clinical Study

The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers

1Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China
2Chinese Cochrane Centre, Chinese EBM Centre, West China Hospital, Sichuan University, Chengdu 610041, China

Received 17 July 2014; Revised 11 September 2014; Accepted 30 September 2014

Academic Editor: Konstantinos Papatheodorou

Copyright © 2015 Lan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. G. Armstrong and E. B. Jude, “The role of matrix metalloproteinases in wound healing,” Journal of the American Podiatric Medical Association, vol. 92, no. 1, pp. 12–18, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. V. L. Martins, M. Caley, and E. A. O'Toole, “Matrix metalloproteinases and epidermal wound repair,” Cell and Tissue Research, vol. 351, no. 2, pp. 255–268, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S. V. McLennan, D. Min, and D. K. Yue, “Matrix metalloproteinases and their roles in poor wound healing in diabetes,” Wound Practice and Research, vol. 16, no. 3, pp. 116–121, 2008. View at Google Scholar
  4. C. Soo, W. W. Shaw, X. Zhang, M. T. Longaker, E. W. Howard, and K. Ting, “Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair,” Plastic and Reconstructive Surgery, vol. 105, no. 2, pp. 638–647, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Falanga, “Wound healing and its impairment in the diabetic foot,” The Lancet, vol. 366, no. 9498, pp. 1736–1743, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. N.-B. Yuan, C. Wang, Y. Wang et al., “The preliminary application of autologous platelet-rich gel used to treat refractory diabetic dermal ulcer,” Journal of Sichuan University (Medical Science Edition), vol. 38, no. 5, pp. 900–903, 2007 (Chinese). View at Google Scholar · View at Scopus
  7. V. R. Driver, J. Hanft, C. P. Fylling, and J. M. Beriou, “A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers,” Ostomy Wound Management, vol. 52, no. 6, pp. 68–87, 2006. View at Google Scholar · View at Scopus
  8. Y. Wang, C. Wang, L. P. He et al., “A prospective randomized controlled study on topical autologous platelet-rich plasma gel for the treatment of diabetic non-healing dermal ulcers,” Chinese Journal of Diabetes, vol. 11, no. 17, pp. 822–825, 2009 (Chinese). View at Google Scholar
  9. N. B. Yuan, Y. Long, X. X. Zhang, and X. W. Ran, “Study on the mechanism of autologous platelet-rich gel to treat the refractory diabetic dermal ulcers,” Journal of Sichuan University (Medical Science Edition), vol. 40, no. 2, pp. 292–294, 2009 (Chinese). View at Google Scholar · View at Scopus
  10. Y. Yang, H. Liu, G. Liu, and X. Ran, “Antibacterial effect of autologous platelet-rich gel derived from health volunteers in vitro,” Chinese Journal of Reparative and Reconstructive Surgery, vol. 24, no. 5, pp. 571–576, 2010 (Chinese). View at Google Scholar · View at Scopus
  11. L. Chen, C. Wang, H. Liu, G. Liu, and X. Ran, “Antibacterial effect of autologous platelet-rich gel derived from subjects with diabetic dermal ulcers in vitro,” Journal of Diabetes Research, vol. 2013, Article ID 269527, 5 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Toriseva and V.-M. Kähäri, “Proteinases in cutaneous wound healing,” Cellular and Molecular Life Sciences, vol. 66, no. 2, pp. 203–224, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. P. He, C. Wang, D. W. Chen, X. J. Li, and X. W. Ran, “Dynamic changes of MMP-1, MMP-9 and TIMP-1 in the refractory diabetic dermal ulcers treated by autologous platelet-rich gel,” Journal of Sichuan University (Medical Science Edition), vol. 43, no. 5, pp. 757–761, 2012 (Chinese). View at Google Scholar · View at Scopus
  14. N. Yuan, C. Wang, Y. Wang et al., “Preparation of autologous platelet-rich gel for diabetic refractory dermal ulcer and growth factors analysis from it,” Chinese Journal of Reparative and Reconstructive Surgery, vol. 22, no. 4, pp. 468–471, 2008 (Chinese). View at Google Scholar · View at Scopus
  15. M. Cáceres, C. Martínez, J. Martínez, and P. C. Smith, “Effects of platelet-rich and -poor plasma on the reparative response of gingival fibroblasts,” Clinical Oral Implants Research, vol. 23, no. 9, pp. 1104–1111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. H. S. Shin and H. Y. Oh, “The effect of platelet-rich plasma on wounds of OLETF rats using expression of matrix metalloproteinase-2 and -9 mRNA,” Archives of Plastic Surgery, vol. 39, no. 2, pp. 106–112, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. T. W. Axelrad, D. D. Deo, P. Ottino et al., “Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration,” The FASEB Journal, vol. 18, no. 3, pp. 568–590, 2004. View at Google Scholar · View at Scopus