Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice

Figure 1

HDC^−/− mice are partially resistant to the development of autoimmune diabetes. (a) Cumulative incidence of spontaneous diabetes in female HDC^+/+ () and HDC^−/− strains (). Mice were considered diabetic when glycemia >2.5 g/L. (b) Serum levels of IL-6, IFNγ, IL-12, and leptin in HDC^−/− NOD and NOD female mice. For measuring leptin, serum was obtained from starved mice. Data are presented as means ± s.e.m. , HDC^−/− versus HDC^+/+ mice determined by Student’s -test. ().

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