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Journal of Diabetes Research
Volume 2016, Article ID 1342643, 5 pages
Research Article

Intercellular Adhesion Molecule and Endogenous NOS Inhibitor: Asymmetric Dimethylarginine in Pregnant Women with Gestational Diabetes Mellitus

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland

Received 23 October 2015; Revised 8 January 2016; Accepted 13 January 2016

Academic Editor: Ilaria Campesi

Copyright © 2016 Elżbieta Poniedziałek-Czajkowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of the study was to evaluate the concentrations of soluble intercellular adhesion molecule-1 (s-ICAM-1) and endogenous NOS inhibitor, asymmetric dimethylarginine (ADMA), as markers of endothelium dysfunction in patients with gestational diabetes mellitus (GDM). Patients and Methods. The levels of s-ICAM-1 and ADMA were analysed in the group of 56 patients with GDM and compared to 25 healthy pregnant women. The concentrations of s-ICAM-1 and ADMA were measured in serum using ELISA tests. Results. The groups did not differ by baseline descriptors: age ( versus years, NS) and gestational age ( versus hbd, NS). The patients with GDM were more obese (BMI versus  kg/m2, ) and had higher concentration of C-reactive protein ( versus  mg/L, ). In the GDM group the level of ADMA was lower ( versus μmol/L, ) and the level of s-ICAM-1 was significantly higher (.12 versus  ng/mL, ) compared to controls. Conclusions. The pregnant women with GDM are characterized by higher concentration of s-ICAM-1 that reflects the activation and dysfunction of the endothelial cells. The decreased ADMA level in GDM patients seems to be preventive in the limitation of NO synthesis caused by the impaired insulin action and the endothelial dysfunction.