ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Figure 6

Disulfiram (DSF) pretreatment and mitochondrial oxygen consumption rate (OCR). (a) Basal mitochondrial OCR from G1, G2, G3, and G4 which depict mannitol, high glucose stress, DSF + mannitol, and DSF + high glucose stress. = 4–6. (b) Maximal mitochondrial OCR with FCCP treatment. G1, G2, G3, and G4 depict mannitol, high glucose stress, DSF + mannitol, and DSF + high glucose stress, respectively. = 4–6. versus G1, versus G2, and versus G3.

(a)

(b)