Screening of Undiagnosed Hypothyroidism in Elderly Persons with Diabetes according to Age-Specific Reference Intervals for Serum Thyroid Stimulating Hormone and the Impact of Antidiabetes Drugs

Table 2

Laboratory data in euthyroid patients and occurrence of hypothyroidism and autoimmunity in hypothyroid patients with diabetes and persons without diabetes.

Data	Patients with diabetes	Persons without diabetes	values
TSH (mU/L)
Median	3.3	3.2	NS
25–75%	1.1–4.3	1.3–4.2
95% CI	3.1–4.7	2.9–3.9
FT4 (pmol/L)
Mean	14.2	15.4	NS
SD	±3.9	±2.6
95% CI	14.5–15.2	14.2–15.4
Positive TPOAb (%) in euthyroid patients	13.8% (104/751)	8.3% (34/409)	0.027
Hypothyroidism (%/)	6.4% (45/751)	5.1% (21/409)	0.0038
Positive TPOAb (%) in hypothyroid patients	64.4% (29/45)	34% (7/21)	<0.0001

TSH: thyroid stimulating hormone; FT4: free thyroxine; 25–75%: 25–75 percentiles; CI: confidence interval; NS: not significant. For converting FT4 in nd/dL, multiply pmol/L by 0.078.