Vascular Endothelial Growth Factor Gene Polymorphism (rs2010963) and Its Receptor, Kinase Insert Domain-Containing Receptor Gene Polymorphism (rs2071559), and Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Table 3

Comparison of markers of carotid atherosclerosis (CIMT, sum of plaque thickness, and number of involved segments) in subjects with T2DM at the beginning of the study with regard to the rs2010963 and rs2071559 genotypes.

rs2010963	Mean (95% CI)				Linear trend analysis
	CC (52)	CG (280)	GG (263)
CIMT (μm)	1045 ± 192; (969–1121)	996 ± 210; (964–1026)	1026 ± 210; (995–1058)	0.27	2.29	0.13
Sum of plaque thickness (mm)	7.58 ± 4.52; (5.67–9.49)	7.79 ± 4.28; (7.09–8.48)	8.11 ± 4.73; (7.35–8.88)	0.76	0.009	0.93
Number of involved segments	2.67 ± 1.51; (2.07–3.26)	2.48 ± 1.70; (2.24–2.73)	2.54 ± 1.60; (2.31–2.77)	0.84	0.34	0.56
rs2071559	Mean (95% CI)				Linear trend analysis
	CC (131)	TC (309)	TT (155)
CIMT (μm)	1053 ± 186; (1012–1092)	1029 ± 200; (987–1070)	988 ± 219; (958–1019)	0.04	5.64	0.04
Sum of plaque thickness (mm)	8.81 ± 4.30; (7.83–9.78)	8.27 ± 4.50; (7.26–9.29)	7.31 ± 4.48; (6.61–8.00)	0.03	5.91	0.02
Number of involved segments	2.87 ± 1.41; (0.94–1.65)	2.38 ± 1.60; (0.95–1.73)	2.24 ± 1.70; (0.98–1.46)	0.64	0.22	0.83