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Journal of Diabetes Research
Volume 2016, Article ID 1527932, 8 pages
http://dx.doi.org/10.1155/2016/1527932
Clinical Study

Glucose >200 mg/dL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes

1Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
2Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
3Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, 13123 E 16th Ave, Aurora, CO 80045, USA
4Colorado School of Public Health and University of Colorado, 13001 East 17th Place, Campus Box B119, Aurora, CO 80045, USA

Received 17 June 2016; Revised 30 September 2016; Accepted 3 November 2016

Academic Editor: David Zangen

Copyright © 2016 J. L. Taylor-Cousar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rationale. Cystic fibrosis related diabetes (CFRD) is the most common comorbidity in patients with CF. In spite of increased screening, diagnosis, and treatment of CFRD, the mortality rate in patients with CFRD still far exceeds the mortality rate in those without CFRD. Guidelines suggest that screening for CFRD be performed annually using the 2-hour 75-gram oral glucose tolerance test (OGTT). Adherence to recommended screening has been poor, with only approximately one-quarter of adults with CF undergoing OGTT in 2014. Use of continuous glucose monitoring (CGM) for diagnosis may become an alternative. Objectives. Our objective was to determine whether abnormal CGM predicts subsequent development of CFRD, lung function, and body mass index (BMI) decline and increased rate of CF pulmonary exacerbations in adults with CF. Methods. In a prospective single center pilot trial from September 2009 to September 2010, 21 adult patients due for routine OGTT were recruited to complete simultaneous 3-day CGM and 2-hour 75 gram OGTT. Subsequently, clinical information was reviewed from 2008 to 2015. Conclusions. There was a moderate correlation between interpreted results of 2-hour OGTT and CGM (); CGM indicated a greater level of glucose impairment than OGTT. Glucose >200 mg/dL by CGM predicted development of CFRD ().