Research Article
Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
Table 6
Interrelation among AGE, RAGE, TGF-β1, and TGF-β1 receptor expressions.
| | Parameter | Multiple linear regression equation | values | values | values | Independent |
| | Mucosa-AGE | AGE-M = 0.0812 + (0.372 RAGE-M) + (0.0661 TGF-M) − (0.0259 TGFR-M) | 0.431 | 1.026 | 0.421 | RAGE-M
TGF-M
TGFR-M | 0.173
0.660
0.903 |
| | Muscle-AGE | AGE-Mu = −0.0919 + (0.640 RAGE-Mu) + (0.161 TGF-Mu) + (0.409 TGFR-Mu) | 0.726 | 5.004 | 0.007 | RAGE-Mu
TGF-Mu
TGFR-Mu | 0.012
0.576
0.329 |
| | Submucosa-AGE | AGE-Sub = −0.0559 + (0.294 RAGE-Sub) + (0.134 TGF-Sub) + (0.185 TGFR-Sub) | 0.707 | 4.492 | 0.011 | RAGE-Sub
TGF-Sub
TGFR-Sub | 0.014
0.336
0.272 |
| | Mucosa-RAGE | RAGE-M = 0.0390 + (0.271 AGE-M) − (0.135 TGF-M) + (0.492 TGFR-M) | 0.785 | 7.235 | 0.001 | AGE-M
TGF-M
TGFR-M | 0.173
0.284
0.002 |
| | Muscle-RAGE | RAGE-Mu = 0.232 + (0.477 AGE-Mu) − (0.367 TGF-Mu) + (0.423 TGFR-Mu) | 0.752 | 5.846 | 0.003 | AGE-Mu
TGF-Mu
TGFR-Mu | 0.012
0.129
0.240 |
| | Submucosa-RAGE | RAGE-Sub = 0.302 + (0.985 AGE-Sub) − (0.363 TGF-Sub) − (0.00665 TGFR-Sub) | 0.720 | 4.842 | 0.008 | AGE-Sub
TGF-Sub
TGFR-Sub | 0.014
0.147
0.983 |
| | Mucosa-TGF-β1 | TGF-M = 0.0934 + (0.166 AGE-M) − (0.469 RAGE-M) + (0.608 TGFR-M) | 0.501 | 1.511 | 0.241 | AGE-M
RAGE-M
TGFR-M | 0.660
0.284
0.057 |
| | Muscle-TGF-β1 | TGF-Mu = 0.145 + (0.110 AGE-Mu) − (0.335 RAGE-Mu) + (0.809 TGFR-Mu) | 0.664 | 3.553 | 0.026 | AGE-Mu
RAGE-Mu
TGFR-Mu | 0.576
0.129
0.012 |
| | Submucosa-TGF-β1 | TGF-Sub = 0.212 + (0.384 AGE-Sub) − (0.311 RAGE-Sub) + (0.309 TGFR-Sub) | 0.670 | 3.669 | 0.0242 | AGE-Sub
RAGE-Sub
TGFR-Sub | 0.336
0.147
0.279 |
| | Mucosa-TGF-β1 receptor | TGFR-M = 0.0521 − (0.0329 AGE-M) + (0.860 RAGE-M) + (0.307 TGF-M) | 0.778 | 6.882 | 0.002 | AGE-M
RAGE-M
TGF-M | 0.903
0.002
0.057 |
| | Muscle TGF-β1 receptor | TGFR-Mu = 0.145 + (0.129 AGE-Mu) + (0.179 RAGE-Mu) + (0.375 TGF-Mu) | 0.785 | 7.245 | 0.001 | AGE-Mu
RAGE-Mu
TGF-Mu | 0.329
0.240
0.012 |
| | Submucosa-TGF-β1 receptor | TGFR-Sub = 0.366 + (0.361 AGE-Sub) − (0.00387 RAGE-Sub) + (0.210 TGF-Sub) | 0.757 | 6.055 | 0.003 | AGE-Sub
RAGE-Sub
TGF-Sub | 0.272
0.983
0.279 |
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Notes: M, mucosa; Mu, muscle; Sub, submucosa.
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