Journal of Diabetes Research / 2016 / Article / Fig 1

Research Article

The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells

Figure 1

AS not only induces NIT-1 β cell death but also reduces insulin secretion. (a) Significantly dose-dependent cell death induced by AS in NIT-1 cells; no cell death in PS-treated cells. (b) Insulin secretion decreased considerably in NIT-1 cells after AS treatment and PS treatment with an increased dose. (c) The 48 h incubation of AS evidently increased the content of LDH in NIT-1 cells. Data are presented as mean ± SD from three independent experiments ( compared to the untreated group, t-test). The value for the CON group was set at 1.

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