The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells
Suppression of PARP1 inhibits AS-mediated necrosis and AS-induced cell death. (a) NIT-1 cells cultured with AS treatment exhibited dependent activation of PARP1, PAR, and AMPK and reduced phosphorylated p70S6K compared with BAF-A1 negative autophagy control; the expression was reduced considerably compared to RAPA positive autophagy control. DPQ (PARP1 inhibitor) blocked AS-mediated PARP1, PAR, and AMPK upregulation. BAF-A1 markedly induced P-p70S6K formation; RAPA almost completely eliminated P-p70S6K. (b) PS treatment caused the significant upregulation of PARP1, PAR, and AMPK phosphorylation but a downregulation of p70S6K phosphorylation. DPQ significantly blocked PS-mediated PARP1, PAR, and AMPK upregulation. BAF-A1 also did markedly change P-p70S6K formation; RAPA almost completely eliminated P-p70S6K (, compared to the untreated group; , compared to the only AS- or PS-treated group; mean ± SD from three replicates).
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