Journal of Diabetes Research / 2016 / Article / Fig 7

Research Article

The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells

Figure 7

Confocal microscopic studies on AS-induced mitochondrial morphologic changes in NIT-1 cells. Cells were exposed to 20 μM AS or 20 μM PS with or without DPQ, BAF-A1, and RAPA pretreatment and stained with MitoTracker Red. After 48 h of AS treatment (a), the cells exhibited substantially less red fluorescent staining and mitochondria than the control (decreased 0.6-fold) and contained round, discrete mitochondria and diffused weak cytoplasmic fluorescence, which increased red fluorescence and improved mitochondrial morphology after DPQ treatment. PS-treated cells (b) exhibited mildly decreased red fluorescence and mitochondria compared with the control (decreased 0.1-fold) and showed improved diffused weak cytoplasmic fluorescence after DPQ treatment. Magnification: ×40. Scale bar: 20 μM.

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