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Journal of Diabetes Research
Volume 2016, Article ID 1925424, 7 pages
http://dx.doi.org/10.1155/2016/1925424
Research Article

Levels of Serum 25(OH)VD3, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio

Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China

Received 28 October 2015; Revised 25 January 2016; Accepted 14 February 2016

Academic Editor: Giovanni Annuzzi

Copyright © 2016 Ying Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q.-Y. Wang, Q.-H. Guan, and F.-Q. Chen, “The changes of platelet-derived growth factor-BB (PDGF-BB) in T2DM and its clinical significance for early diagnosis of diabetic nephropathy,” Diabetes Research and Clinical Practice, vol. 85, no. 2, pp. 166–170, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Wu, Q. Wang, C. Lv et al., “The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin,” Diabetes Research and Clinical Practice, vol. 106, no. 2, pp. 343–350, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Nakagawa, W. Sato, T. Kosugi, and R. J. Johnson, “Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy,” Journal of Diabetes Research, vol. 2013, Article ID 184539, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Z. Costa and R. Soares, “Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox,” Life Sciences, vol. 92, no. 22, pp. 1037–1045, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Cheng and R. C. Harris, “Renal endothelial dysfunction in diabetic nephropathy,” Cardiovascular and Hematological Disorders—Drug Targets, vol. 14, no. 1, pp. 22–33, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Matoba, D. Kawanami, R. Okada et al., “Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α,” Kidney International, vol. 84, no. 3, pp. 545–554, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C. C. Khoury and F. N. Ziyadeh, “Angiogenic factors,” Contributions to Nephrology, vol. 170, pp. 83–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Eleftheriadis, G. Antoniadi, G. Pissas, V. Liakopoulos, and I. Stefanidis, “The renal endothelium in diabetic nephropathy,” Renal Failure, vol. 35, no. 4, pp. 592–599, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. R. B. Goldberg, “Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications,” The Journal of Clinical Endocrinology & Metabolism, vol. 94, no. 9, pp. 3171–3182, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Persson, P. Rossing, P. Hovind et al., “Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA 2) study,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 68, no. 8, pp. 731–738, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Kamenický, G. Mazziotti, M. Lombès, A. Giustina, and P. Chanson, “Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications,” Endocrine Reviews, vol. 35, no. 2, pp. 234–281, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Mao, F. Ji, Y. Liu, W. Zhang, and X. Ma, “Calcitriol plays a protective role in diabetic nephropathy through anti-inflammatory effects,” International Journal of Clinical and Experimental Medicine, vol. 7, no. 12, pp. 5437–5444, 2014. View at Google Scholar · View at Scopus
  13. F. Jiang, Y.-T. Tang, L. Guo, and X.-Y. Jiao, “The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes,” Annals of Clinical and Laboratory Science, vol. 43, no. 1, pp. 37–44, 2013. View at Google Scholar · View at Scopus
  14. D. H. Yu, K. A. MacE, S. L. Hansen, N. Boudreau, and D. M. Young, “Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-α protein synthesis and function during cutaneous repair in diabetic mice,” Wound Repair and Regeneration, vol. 15, no. 5, pp. 628–635, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Ben-Shoshan, S. Amir, D. T. Dang, L. H. Dang, Y. Weisman, and N. J. Mabjeesh, “1α,25-Dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells,” Molecular Cancer Therapeutics, vol. 6, no. 4, pp. 1433–1439, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. S. Kim, S. H. Song, I. J. Kim et al., “Clinical implication of urinary tubular markers in the early stage of nephropathy with type 2 diabetic patients,” Diabetes Research and Clinical Practice, vol. 97, no. 2, pp. 251–257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Isoe, Y. Makino, K. Mizumoto et al., “High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein,” Kidney International, vol. 78, no. 1, pp. 48–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Bondeva, J. Heinzig, C. Ruhe, and G. Wolf, “Advanced glycated end-products affect HIF-transcriptional activity in renal cells,” Molecular Endocrinology, vol. 27, no. 11, pp. 1918–1933, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Tang, R. Yi, B. Yang, H. Li, H. Chen, and Z. Liu, “Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats,” Diabetes Research and Clinical Practice, vol. 97, no. 1, pp. 125–131, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Verrotti, R. Greco, F. Basciani, G. Morgese, and F. Chiarelli, “Von Willebrand factor and its propeptide in children with diabetes. Relation between endothelial dysfunction and microalbuminuria,” Pediatric Research, vol. 53, no. 3, pp. 382–386, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Yngen, C.-G. Östenson, P. Hjemdahl, and N. H. Wallén, “Meal-induced platelet activation in Type 2 diabetes mellitus: effects of treatment with repaglinide and glibenclamide,” Diabetic Medicine, vol. 23, no. 2, pp. 134–140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. N. G. Cruz, L. P. Sousa, M. O. Sousa, N. T. Pietrani, A. P. Fernandes, and K. B. Gomes, “The linkage between inflammation and Type 2 diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 99, no. 2, pp. 85–92, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Jazayeri, A. Allameh, M. Soleimani, S. H. Jazayeri, A. Piryaei, and S. Kazemnejad, “Molecular and ultrastructural characterization of endothelial cells differentiated from human bone marrow mesenchymal stem cells,” Cell Biology International, vol. 32, no. 10, pp. 1183–1192, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Poulaki, A. M. Joussen, N. Mitsiades, C. S. Mitsiades, E. F. Iliaki, and A. P. Adamis, “Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy,” The American Journal of Pathology, vol. 165, no. 2, pp. 457–469, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Ji, X.-X. Yin, Z.-M. Wu, J.-Y. Wang, Q. Lu, and Y.-Y. Gao, “Ginkgo biloba extract prevents glucose-induced accumulation of ECM in rat mesangial cells,” Phytotherapy Research, vol. 23, no. 4, pp. 477–485, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. S.-B. Catrina, I. R. Botusan, A. Rantanen et al., “Hypoxia-inducible factor-1α and hypoxia-inducible factor-2α are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I,” Clinical Cancer Research, vol. 12, no. 15, pp. 4506–4514, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. L. A. Plum and J. B. Zella, “Vitamin D compounds and diabetic nephropathy,” Archives of Biochemistry and Biophysics, vol. 523, no. 1, pp. 87–94, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. Ren, W. Li, Q. Zhao, L. Ma, and J. Zhu, “The impact of 1,25-dihydroxy vitamin D3 on the expressions of vascular endothelial growth factor and transforming growth factor-β1 in the retinas of rats with diabetes,” Diabetes Research and Clinical Practice, vol. 98, no. 3, pp. 474–480, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Yildirim, T. Guler, M. Akbulut, O. Oztekin, and G. Sariiz, “1-alpha, 25-dihydroxyvitamin D3 regresses endometriotic implants in rats by inhibiting neovascularization and altering regulation of matrix metalloproteinase,” Postgraduate Medicine, vol. 126, no. 1, pp. 104–110, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Munisamy, M. D. Kamaliah, A. H. Suhaidarwani, W. M. Zahiruddin, and A. H. Rasool, “Impaired microvascular endothelial function in vitamin D-deficient diabetic nephropathy patients,” Journal of Cardiovascular Medicine, vol. 14, no. 6, pp. 466–471, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Hirano, “Abnormal lipoprotein metabolism in diabetic nephropathy,” Clinical and Experimental Nephrology, vol. 18, no. 2, pp. 206–209, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Bjornstad, M. A. Lanaspa, T. Ishimoto et al., “Fructose and uric acid in diabetic nephropathy,” Diabetologia, vol. 58, no. 9, pp. 1993–2002, 2015. View at Publisher · View at Google Scholar