Research Article

Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Figure 6

Effects of MG on expression of p-JNK, JNK, p-P38, and P38 proteins in MIN6 cells. The expression of p-JNK and JNK (a) and p-P38 and P38 (d) was increased by MG. Cells were incubated with 0.05 or 0.1 mM MG for 3 h. Results shown in (b), (c), (e), and (f) are fold change compared to baseline (0 mM MG + 0 mM NAC). The effects of MG on MIN6 were reversed by coincubation with NAC. , , and compared to control group (0 mM MG + 0 mM NAC). compared to the higher MG group (0.1 mM MG + 0 mM NAC).
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