Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients

Table 3

Partial correlations between betatrophin levels and glucose-related variables in T2DM subjects.

Characteristics	Model 1		Model 2		Model 3
		P-value	Partial r	P-value	Partial r	P-value
HbA1c	0.026	0.765	0.129	0.174	0.057	0.566
FBG	−0.112	0.194	−0.053	0.577	−0.044	0.659
Fasting insulin	−0.080	0.354	−0.044	0.644	−0.103	0.296
Fasting C-peptide	0.019	0.828	0.015	0.878	0.035	0.719
AUC0.5	0.007	0.936	0.032	0.738	0.058	0.555
AUC1	0.005	0.961	0.023	0.809	0.056	0.572
AUC2	−0.007	0.940	−0.002	0.984	0.035	0.726
HOMA2-%B	0.130	0.140	0.087	0.363	0.080	0.419
HOMA2-%S	0.028	0.753	0.044	0.642	0.037	0.709
HOMA2-IR	−0.015	0.865	0.005	0.954	0.016	0.872

Model 1: unadjusted.
Model 2: adjusted for age, gender, and BMI.
Model 3: adjusted for age, gender, BMI, triglyceride, cholesterol, use of insulin, insulin secretagogues treatment, other antidiabetic medications, and duration of diabetes.