Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes

Figure 2

Gene network showing associations between genes that were differentially expressed in the DM and MM states relative to controls (genes of Figure 2 are listed in Supplemental Table 1). Nodes of the network represent genes that are grouped by their involvement in biological process as defined by the Gene Ontology and are colored accordingly (light blue denotes genes involved in DNA replication; gray, in chromatin remodeling; orange, in DNA methylation; green, in DNA recombination; yellow, in DNA repair; and brown, in DNA topological change). Diamond-shaped nodes represent genes with differentially methylated regions. Gene interactions confirmed experimentally and by coexpression are shown as black lines connecting nodes; red dotted lines show associations derived only from coexpression data; and green lines denote interactions confirmed by only experimental evidences.