A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice
(a) Glo1 protein levels measured via Western blot were significantly reduced in the kidney (), whereas protein levels in the heart () and the liver () did not differ significantly. (b) Glo1 activity was significantly reduced in the heart (), kidney (), and liver () of Glo1KD mice in comparison to wild-type animals (). Glo1 activity in the liver of wild-type mice was arbitrarily set to 100%. (c) The levels of methylglyoxal-derived AGEs were measured via an ELISA. There was no significant impact of the Glo1 knockdown on the methylglyoxal-derived AGEs in extracts of heart, kidney, and liver ().
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