The Expanded Bead Size of Corneal C-Nerve Fibers Visualized by Corneal Confocal Microscopy Is Associated with Slow Conduction Velocity of the Peripheral Nerves in Patients with Type 2 Diabetes Mellitus

Table 3

Differentiating efficacy of corneal nerve fiber parameters as AUC and values with CCM cut-off with sensitivity and specificity between control subjects and type 2 diabetic patients without neuropathy or between type 2 diabetic patients with or without neuropathy.

Variable	⁢Between control subjects and type 2 diabetic patients without neuropathy					⁢Between type 2 diabetic patients without or with neuropathy
	AUC	value	Cut-off	Sensitivity	Specificity	AUC	value	Cut-off	Sensitivity	Specificity
CNFD	0.847	<0.0001	28.1/mm^2	0.79	0.78	0.610	0.020	23.1/mm^2	0.66	0.54
CNFL	0.830	<0.0001	13.4 mm/mm^2	0.79	0.68	0.585	0.071	11.6 mm/mm^2	0.63	0.55
BF	0.883	<0.0001	22.1/0.1 mm	0.92	0.83	0.538	0.427	20.5/0.1 mm	0.48	0.66
BS	0.997	<0.0001	8.47 μm^2	0.99	0.96	0.602	0.031	9.76 μm^2	0.65	0.53

BF, beading frequency; BS, bead size; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length.