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Journal of Diabetes Research
Volume 2016, Article ID 3805372, 6 pages
Research Article

Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients

1Department of Endocrinology and Metabolism, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
2Department of Endocrinology, Shanghai Songjiang Center Hospital, Shanghai 201600, China
3Department of Laboratory Medicine, Shanghai Songjiang Center Hospital, Shanghai 201600, China

Received 1 February 2016; Revised 11 May 2016; Accepted 15 May 2016

Academic Editor: Giovanni Annuzzi

Copyright © 2016 Nengguang Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Across-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD in type 2 diabetic patients. Clinical parameters including SUA were determined and NAFLD was diagnosed by ultrasonography. SUA was significantly higher in type 2 diabetic subjects with NAFLD than in those without NAFLD in men, but not in women. Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37.9%, 58.6%, and 72.6%, resp., for trend < 0.001). After adjusting for confounding factors, the odd ratios (95% CI) for NAFLD were 1 (reference), 2.93 (95%CI 1.25–6.88), and 3.93 (95% CI 1.55–9.98), respectively, across the tertiles of SUA in men. Contrastingly, SUA levels in women were not independently associated with the risk of NAFLD. Our data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors.