Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats
Table 4
Effect of plant extracts on percentage of insulin secreting β-cells and diameter of islets in the pancreas of streptozotocin induced diabetic rats after 30 days of treatment.
Treatment
Percentage area of insulin secreting cells in islets (%)
Diameter of islets (µm)
Small
Average
Large
Small
Average
Large
Healthy untreated
86.17 ± 3.54
72.00 ± 3.90
78.33 ± 7.53
86.80 ± 1.32
138.50 ± 5.57
173.16 ± 8.97
Diabetic untreated
9.17 ± 0.91
7.50 ± 1.23
6.83 ± 0.87
32.34 ± 1.55
127.43 ± 2.70
153.05 ± 0.37
G. arborea (1.00 g/kg)
60.89 ± 3.34
48.78 ± 4.78
69.00 ± 4.99
37.12 ± 2.13
137.00 ± 2.07
164.34 ± 2.56
Glibenclamide (0.50 mg/kg)
33.33 ± 2.34
10.00 ± 0.15
7.17 ± 1.42
36.10 ± 3.31
128.38 ± 1.99
154.08 ± 5.88
The values are expressed as mean ± SEM (/group). Statistically significant from streptozotocin induced diabetic control rats at (ANOVA followed by Dunnett’s test).