Research Article

Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats

Table 4

Effect of plant extracts on percentage of insulin secreting β-cells and diameter of islets in the pancreas of streptozotocin induced diabetic rats after 30 days of treatment.

TreatmentPercentage area of insulin
secreting cells in islets (%)
Diameter of islets (µm)
SmallAverageLargeSmallAverageLarge

Healthy untreated86.17 ± 3.5472.00 ± 3.9078.33 ± 7.5386.80 ± 1.32138.50 ± 5.57173.16 ± 8.97
Diabetic untreated9.17 ± 0.917.50 ± 1.236.83 ± 0.8732.34 ± 1.55127.43 ± 2.70153.05 ± 0.37
G. arborea (1.00 g/kg)60.89 ± 3.3448.78 ± 4.7869.00 ± 4.9937.12 ± 2.13137.00 ± 2.07164.34 ± 2.56
Glibenclamide (0.50 mg/kg)33.33 ± 2.3410.00 ± 0.157.17 ± 1.4236.10 ± 3.31128.38 ± 1.99154.08 ± 5.88

The values are expressed as mean ± SEM (/group). Statistically significant from streptozotocin induced diabetic control rats at (ANOVA followed by Dunnett’s test).