Oxidative Damage to the Salivary Glands of Rats with Streptozotocin-Induced Diabetes-Temporal Study: Oxidative Stress and Diabetic Salivary Glands
Table 2
Comparison of the examined parameters between parotid and submandibular glands of the control and streptozotocin-diabetic rats.
Group
PG
SMG
PG : SMG
Salivary glands weight (g) M (min–max)
C1
0.09 (0.08–0.12)
0.19 (0.18–0.22)
ns
C2
0.09 (0.79–0.13)
0.21 (0.17–0.24)
ns
DM1
0.09 (0.07–0.09)
0.21 (0.14–0.24)
ns
DM2
0.07 (0.06–0.09)
0.18 (0.11–0.19)
ns
TAS (mol/mg of protein) M (min–max)
C1
2.84 (2.01–3.81)
1.94 (1.75–2.06)
<0.005 (↑)
C2
2.69 (2.15–2.99)
1.89 (1.84–2.10)
<0.005 (↑)
DM1
2.36 (2.30–2.89)
2.16 (2.10–2.30)
<0.05 (↑)
DM2
1.40 (0.42–1.74)
1.76 (1.17–1.82)
ns
TOS (mol/mg of protein) M (min–max)
C1
0.04 (0.02–0.21)
0.014 (0.01–0.11)
<0.0005 (↑)
C2
0.042 (0.02–0.26)
0.02 (0.01–0.30)
<0.005 (↑)
DM1
0.057 (0.05–0.08)
0.02 (0.018–0.021)
<0.0005 (↑)
DM2
0.067 (0.01–0.09)
0.03 (0.008–0.04)
<0.005 (↑)
OSI M (min–max)
C1
14.08 (6.32–17.52)
7.22 (7.17–12.17)
ns
C2
15.61 (5.21–22.5)
10.58 (4.97–19.35)
ns
DM1
24.15 (19.97–39.81)
9.26 (6.67–12.54)
<0.0005 (↑)
DM2
47.86 (36.52–59.86)
17.05 (6.02–25.33)
<0.0005 (↑)
PC (nmol/mg of protein) M (min–max)
C1
0.051 (0.025–0.10)
0.051 (0.019–0.065)
ns
C2
0.055 (0.019–0.100)
0.049 (0.016–0.070)
ns
DM1
0.061 (0.058–0.084)
0.056 (0.036–0.064)
<0.05 (↑)
DM2
0.068 (0.039–0.127)
0.061 (0.040–0.136)
<0.05 (↑)
4-HNE protein adduct (g/mg of protein) M (min–max)
C1
0.32 (0.24–0.38)
0.30 (0.28–0.34)
ns
C2
0.34 (0.30–0.39)
0.36 (0.33–0.37)
ns
DM1
0.46 (0.43–0.57)
0.39 (0.26–0.41)
<0.05 (↑)
DM2
0.65 (0.57–0.74)
0.45 (0.39–0.54)
<0.005 (↑)
oxy-LDL/MDA (ng/mg of protein) M (min–max)
C1
0.31 (0.26–0.33)
0.28 (0.25–0.29)
ns
C2
0.31 (0.22–0.32)
0.29 (0.27–0.32)
ns
DM1
0.37 (0.35–0.49)
0.32 (0.28–0.4)
<0.05 (↑)
DM2
0.38 (0.35–0.53)
0.33 (0.32–0.38)
<0.05 (↑)
8-isoP (pg/mg of protein) M (min–max)
C1
0.022 (0.019–0.029)
0.022 (0.019–0.033)
ns
C2
0.020 (0.015–0.021)
0.019 (0.014–0.025)
ns
DM1
0.023 (0.021–0.057)
0.019 (0.011–0.021)
<0.05 (↑)
DM2
0.028 (0.021–0.044)
0.023 (0.019–0.028)
<0.05 (↑)
8-OHdG (pg/mg of protein) M (min–max)
C1
0.64 (0.30–1.40)
0.57 (0.51–0.61)
ns
C2
0.70 (0.41–2.00)
0.54 (0.49–0.68)
ns
DM1
0.53 (0.31–0.63)
0.52 (0.32–0.63)
ns
DM2
0.91 (0.74–1.65)
0.51 (0.41–0.97)
<0.005 (↑)
C1: control group in the first week of the experiment, C2: control group in the second week of the experiment, DM1: diabetic group in the first week of the experiment, DM2: diabetic group in the first second of the experiment, PG: parotid gland, SMG: submandibular gland, TAS: total antioxidant status, TOS: total oxidant status, OSI: oxidative status index, PC: protein carbonyls, 4-HNE protein adduct: 4-hydroxynonenal protein adduct, oxy-LDL/MDA: oxidized and/or MDA-modified LDL-cholesterol, 8-isoP: 8-isoprostanes, 8-OHdG: 8-hydroxy-D-guanosine, ns: not significant, : statistical significance < 0.05, M: median, min: minimum, max: maximum, and (↑): increase.
