Oxidative Damage to the Salivary Glands of Rats with Streptozotocin-Induced Diabetes-Temporal Study: Oxidative Stress and Diabetic Salivary Glands
Table 3
Plasma TAS, TOS, OSI, protein carbonyls (PC), 4-HNE protein adduct, oxy-LDL/MDA, 8-isoprostanes (8-isoP), and 8-OHdG of the control and streptozotocin-diabetic rats.
TAS (mol/mg of protein) M (min–max)
TOS (mol/mg of protein) M (min–max)
OSI M (min–max)
PC (pmol/mg of protein) M (min–max)
4-HNE protein adduct (ng/mg of protein) M (min–max)
oxy-LDL/MDA (pg/mg of protein) M (min–max)
8-isoP (pg/mg of protein) M (min–max)
8-OHdG (pg/mg of protein) M (min–max)
C1
0.1 (0.06–0.15)
1.03 (0.32–2.44)
1.03 (0.095–1.17)
1.41 (1.07–1.48)
0.004 (0.001–0.005)
1.57 (0.99–2.64)
0.0019 (0.0018–0.0022)
0.20 (0.17–0.24)
C2
0.1 (0.05–0.16)
1.05 (0.88–1.28)
0.7 (0.47–1.13)
1.48 (1.31–2.01)
0.005 (0.001–0.007)
1.62 (1.47–2.24)
0.0018 (0.0011–0.0023)
0.21 (0.19–0.22)
DM1
0.16 (0.09–0.20)
2.84 (2.54–3.27)
1.78 (1.57–2.51)
1.57 (1.51–2.11)
6.8 (6.7–7.5)
2.29 (1.21–2.95)
0.0023 (0.0019–0.0026)
0.26 (0.24–0.30)
DM2
0.077 (0.05–0.15)
2.67 (2.48–2.74)
1.31 (1.21–1.83)
1.59 (1.09–2.19)
6.5 (6.0–7.7)
3.65 (3.08–4.01)
0.0022 (0.0017–0.0026)
0.26 (0.25–0.29)
(C1 : C2)
ns
ns
ns
ns
ns
ns
ns
ns
(DM1 : DM2)
ns
ns
ns
ns
ns
<0.005 (↑)
ns
ns
(C1 : DM1)
ns
<0.0005 (↑)
<0.005 (↑)
<0.05 (↑)
<0.00005 (↑)
<0.05 (↑)
<0.05 (↑)
ns
(C2 : DM2)
<0.05 (↓)
<0.0005 (↑)
<0.005 (↑)
<0.05 (↑)
<0.00005 (↑)
<0.005 (↑)
<0.05 (↑)
<0.05 (↑)
C1: control group in the first week of the experiment, C2: control group in the second week of the experiment, DM1: diabetic group in the first week of the experiment, DM2: diabetic group in the first second of the experiment, TAS: total antioxidant status, TOS: total oxidant status, OSI: oxidative status index, PC: protein carbonyls, 4-HNE protein adduct: 4-hydroxynonenal protein adduct, oxy-LDL/MDA: oxidized and/or MDA-modified LDL-cholesterol, 8-isoP: 8-isoprostanes, 8-OHdG: 8-hydroxy-D-guanosine, ns: not significant, : statistical significance < 0.05, M: median, min: minimum, max: maximum, (↓): decrease, and (↑): increase.
