Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes

Figure 2

Measurements of blood and ISF glucose changes in mice. (a) Time course of blood and ISF glucose concentration changes in mice. (b) Comparisons of glucose changes measured in blood (BG) and interstitial fluid (ISFG) of mice with the time courses generated by the theoretical simulations. For the in vivo studies, six experimental mice (three male and three female) with similar size and weight were used. The mice were fasted for one night before the experiment. is the blood flow and is the glucose extraction from blood related to glucose membrane permeability ensued in the theoretical model.

(a)

(b)