Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats

Table 2

Concentrations of the products of metabolism of exogenously added (to a final concentration of 1 µM) angiotensin I by the aorta fragments pretreated with perindoprilat (final concentration 3 µM) from streptozotocin and saline treated animals (pg/mg of dry tissue; median [25th, 75th percentile]). values are from Kruskal-Wallis nonparametric tests.

Analyte	Concentration in streptozotocin treated rats (), pg/mg of dry tissue; median [25th, 75th percentile]	Concentration in control rats (), pg/mg of dry tissue; median [25th, 75th percentile]	value
Angiotensin I	941.9 [587.3, 1205.7]	884.1 [689.1, 975.3]	0.95
Angiotensin II	2.42 [2.21, 3.07]	2.11 [1.81, 2.59]	0.18
Angiotensin III	3.25 [2.55, 4.07]	2.45 [2.29, 3.85]	0.41
Angiotensin IV	1.10 [0.84, 1.49]	0.79 [0.62, 1.31]	0.18
Angiotensin (1–9)	3.48 [1.69, 4.25]	5.29 [3.65, 7.47]	0.048
Angiotensin (1–7)	2.16 [1.95, 3.28]	2.57 [2.38, 3.63]	0.22
Angiotensin (1–5)	1.19 [0.80, 1.50]	0.95 [0.80, 1.17]	0.65