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Journal of Diabetes Research
Volume 2016, Article ID 4952801, 13 pages
http://dx.doi.org/10.1155/2016/4952801
Research Article

Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia

Department of Obstetrics and Gynecology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China

Received 10 July 2015; Revised 12 October 2015; Accepted 29 October 2015

Academic Editor: Kimber Stanhope

Copyright © 2016 Rina Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1. Pathways of changes in hypermethylation in F1 offspring exposed to intrauterine hyperglycemia. Genes with changes in hypermethylation in perirenal adipose tissue from offpring in the F1-DN and F1-CN groups are identified using a molecular annotation system.

Supplementary Table 2. Pathways of changes in hypomethylation in F1 offspring exposed to intrauterine hyperglycemia.

Supplementary Figure 1. Differences in methylation status of genes related to the adipocytokine signaling pathway and type II diabetes. (A) Differences in hypermethylation in genes related to type II diabetes. (B) Differences in hypomethylation in genes related to the adipocytokine signaling pathway and type II diabetes. Log ratios showed the methylation difference.

  1. Supplementary Material